[Pharmacological modulation of the cholecystokinetic action of Naftusia water]. / Farmakolohichna moduliatsiia kholetsystokinetychnoï diï vody "Naftusia".

In clinical-physiological research with using method of cholecystoultrasonography it is shown, that the most perceptibly increase stimulating action water "Naftusia" on postprandial emptying of gallbladder by its hyperkinesia alpha-adrenoblockers and gastrozepin, and the most effective pharmacons braking stimulation by water hyper- or normokinetic postprandial reaction of gallbladder may consider H2-blockers and platyphyllin.

[The characteristics of disorders of general adaptation reactions in people who suffered as a consequence of the accident at the Chernobyl Atomic Electric Power Station and their correction by means of balneo- and phytotherapy]. / Osoblyvosti porushen' zahal'nykh adaptatsiinykh reaktsii u osib, iaki postrazhdaly vnaslidok avariï na ChAES, ta ïkh korektsiia zasobamy bal'neo- i fitoterapiï.

Pathological general adaptive reactions of the body (GARs) were found out to occur on 33.8 +/- 5.0 of patients with chronic pathologies of the urinary and digestive organs, arriving at the Truskavets health resort from the areas contaminated with radionuclides, compared with 7.0 +/- 2.1% of diseased controls. Complex spa treatment during a period of two weeks involving ingestion of the mineral water "naftusia" has a beneficial effect on pathologic and premorbid GARs though not effectively so. Adaptogenic effect of balneotherapy is potentiated by use of balsam "Kryms'kyi" but not a home preparation ginseng.

[The effect of a lyophilized extract of the mucosa of the proximal small intestine on kidney water- and salt-excretory functions in rats]. / Vplyv liofilizovanoho ekstraktu slyzovoï obolonky proksymal'noho viddilu tonkoï kyshky na vodo- ta solevydil'nu funktsiï nyrok u shchuriv.

Experiments on Wistar rats injected intragastrically deionized water (1 % of the body weight) and intra-abdominally 0.1 mg/kg of the lyophilized water extract (LWE) from the thin intestine have shown that under these conditions diuresis and excretion of K+ with the urine increase and retention of Na+ excretion decreases. After intragastric injection of isotonic NaCl solution, the LWE has exerted only the K-excretion effect. An increase in the LWE doses from 1 to 10 mg/kg has weakened all these reactions. It has been found in experiments in vitro that the LWE has exerted an activatory dose-dependent effect on Na, K-ATPase from the kidney cortex cells.

[Experimental research on the adaptogenic properties of Kryms'kyi balsam]. / Eksperimental'ne doslidzhennia adaptohennykh vlastyvostei bal'zamu "Kryms'kyi".

The effect of balsam "Kryms'kyi" has been studied in chronic experiments on Wistar rats. It is proved that peroral administration of balsam "Kryms'kyi" to rat for 4-7 days enhances excretion of 17-KC, static and dynamic muscular workability, resistance to hypoxia, accelerates elimination of xenobiotics, decreases stress-induced damages of the stomach mucosa, myocardium and lymphopenia. This permits considering the balsam an adaptogen and recommending it for clinical test.

[An analysis of the mechanism of the effect of intragastric calcium and magnesium on the release of gastrin and insulin in dogs]. / Analiz mekhanizmu vplyvu intrahastral'noho kal'tsiiu i mahniiu na vyvil'nennia hastrynu ta insulinu u sobak.

The experiments have been carried out on four intact awake dogs to study the influence of intragastric introduction of deionized water, 5 mmol/l of calcium and magnesium chloride solutions in a dose of 3 ml/kg on release of gastrin and insulin into blood. It is stated that during the first 4 min after infusion of deionized water the release of gastrin decreases by 89 +/- 32 conventional units (c.u.), CaCl2 exerts a more pronounced inhibitory effect (168 +/- 36 c.u.), while MgCl2, on the contrary, increases the gastrin release by 398 +/- 92 c.u. Atropin (0.03 mg/kg, subcutaneous injection, 10 min before infusion) absolutely takes away the gastrin-stimulating effect of magnesium, but it has almost no influence on the gastrin-inhibitory effect of calcium. The latter can be taken away by 62% by ornid (5 mg/kg subcutaneously, 20 min before infusion). Preliminary anaesthesia of the stomach mucosa by trymecain or novocain absolutely remove the effect of both calcium and magnesium. Insulin release remained significantly unchanged in any series of experiments.